December 18, 2018

AB Vista: A new perspective on mode of action of fibre-degrading enzymes




An increased understanding of fibre-degrading enzymes' (NSPase) mode of action is presenting a new perspective on their role in nutritional strategies to improve performance, AB Vista said.

NSPases have been used commercially for more than 30 years. Historically, much of the focus on them was placed on reducing the anti-nutritive effects of fibre - now, the focus is shifting towards their role in generating beneficial breakdown products of fibre.

"We know that some specific breakdown products of NSP are beneficial and play a role in adapting the intestinal microbiota, which in turn can boost fibre utilisation and performance," said AB Vista's research manager, Dr. Gemma Gonzalez Ortiz.

As the enzymes degrade the NSP fraction, short-chain oligosaccharides are produced; these are fermented by bacteria in the gut, giving rise to the production of short-chain fatty acids. This effect has been referred to as a prebiotic effect, and is regarded as one of the mechanisms for NSPase activity.

New research (Bedford and Apajalahti, 2018) explores how NSPase mode of action may be based more than the improvement of fibre digestibility and the fermentation of the oligosaccharides generated.

When fed over an extended period of time, dietary xylanase has been shown to effectively increase the capacity of bacteria inside the caeca to digest fibre. This suggests that xylanases have a "training" effect on the caecal microbiome, resulting in adaptive changes over time towards a greater capacity to degrade fibre. This means that NSPases are doing much more than previously thought – they contribute to the development of a more beneficial microbiota, subsequently enabling more efficient uptake of dietary nutrients by the host animal. 


"We need to think of NSPases as tools to accelerate the ability of the gut microbiome to degrade fibre," said AB Vista's research director, Dr. Mike Bedford.

"Rather than quantitively degrading plant cell wall fibre, these enzymes are in effect increasing the intrinsic fibre-digesting capacity of the animal. This has significant implications with regard to selection of NSPase enzyme classes and dose rate."

- AB Vista

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