August 4, 2011
Adisseo offers way to save acidification costs
When balancing feed with sulphur-containing amino acids, feed producers have the choice between DL-Methionine (RhodimetÂ® NP99) and Methionine Hydroxy-analogue (RhodimetÂ® AT88).
RhodimetÂ® AT88 has similar acidifying benefits than organic acids on improving intestinal microflora and nutrient digestibility in poultry and swine. For example, 2.4 kg of RhodimetÂ® AT88 can spare 0.7 kg of formic acid per tonne of poultry feed, saving at least EUR0.50 (US$0.71) per tonne of feed and even releasing more space in feed formulation.
The first effect of organic acids is to optimise gastric acidification. In vitro trials carried out on a monogastric gut model prove that RhodimetÂ® AT88 decreases the need for HCl gastric secretion to achieve a target pH of 2.
When talking about stomach acidification, nutritionists also pay attention to the buffer effect of feed. "The total buffer effect of a diet can be calculated from the ABC (Acid Binding Capacity) values of each ingredient. The aim is to lower the dietary ABC through organic acid supplementation to reach optimum gastric pH. Modelling the ABC decrease through pKa and molecular weight of the different organic acids has allowed us to develop a practical software to better value all organic acids including hydroxy-analogue of methionine," explains Dr Yves Mercier, Research Manager, Amino Acids and Proteins, at Adisseo.
As an example, the ABC-4 value of formic acid is -17 000 mEq/kg and RhodimetÂ® AT88 about -5 000 mEq/kg.
The in vitro inhibition efficacy of RhodimetÂ® AT88 against Salmonella pullorum, Salmonella typhimurium, Salmonella enteritidis, Clostridium perfringens and Campylobacter jejuni, five standard strains of major enteric pathogens, is closer to potassium diformate and formic acid, at same molecular contents, and stronger than lactic acid.
In vivo trials, also, have shown that RhodimetÂ®AT88 is effective at reducing the global gut microbiota amount and the frequency of detection of Campylobacter species.
Moreover, tests have shown that RhodimetÂ® AT88 also strongly inhibits mould development (up to -50% for Aspergillus flavus or Fusarium verticillioides) at standard feed incorporation rate (2.5 kg/tonne).
One kilogram of RhodimetÂ® AT88 appeared even as efficient as 1.25 kg of potassium sorbate on Fusarium graminum.
The acidifying value of RhodimetÂ® AT88 is largely proven by experimental results reported in scientific publications and communications.
For a more practical use of the acidifying potential of RhodimetÂ® AT88, Adisseo has developed a simple calculator to determine the acid equivalence of RhodimetÂ® AT88 compared to organic acids.