December 1, 2009

 

US study finds more effective bid flu vaccine to protect poultry

 

 

University of Guelph scientists have made a discovery that one of the molecular determinants of the H5N1 bird flu virus can induce immune responses in chickens, which may be used in the future for protecting chickens against bird flu and possibly for control of transmission of the virus from birds to humans, according to researcher Shayan Sharif.
 
The molecular region identified by Sharif's research team is a small peptide contained in the hemagglutinin (HA) antigen, a protein found on the surface of the flu virus.

 

The researchers showed that the peptide is recognised by the chicken's T-cells, which attack the virus directly and also trigger the production of antibodies that help the immune system fight the infection.

 

This is the first time scientists have identified a T-cell epitope of an influenza virus -  a protein on a virus particle recognised by the immune system - in chickens.

 

Sharif also added that influenza viruses are constantly changing and it is possible that the H5 virus could develop into something that is more efficiently transmitted from birds to humans and, from person to person, which may lead  to a pandemic of massive proportions.

 

The H5 bird flu virus is commonly found in wild birds such as migratory waterfowl that are usually unaffected by the virus. They can, however, transmit the virus to a variety of domestic birds including chickens, in which it can cause a range of illness from no signs of disease at all to a severe epidemic that kills all infected birds.

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