April 23, 2004

Paradigm Discovery May Lead To Development Of More Effective Fungicides
 
Paradigm Genetics, Inc. announced the discovery of a novel gene target (Alpha-Aminoadipate Reductase) in the biochemical pathway by which fungi produce lysine - a nutrient necessary for the growth and development of fungi - as well as methods enabling the discovery of chemicals that inhibit gene protein activity within the lysine pathway. The company has just been issued a U.S. patent for the discovery. Chemical compounds discovered by Paradigm's patented method may lead to the development of more effective, less toxic fungicides, which are highly sought after throughout the agricultural industry.
 
"Our scientists were able to identify a second novel target within the lysine synthesis pathway. By inhibiting steps along this critical pathway, we can potentially prevent the growth of fungi known to harm commercial crop production. We believe this discovery will have significant commercial applications, as companies aggressively pursue the development of fungicides that are environmentally safe and more effective than existing products." Keith Davis, Ph.D., Vice President, Agricultural Research, revealed.
 
Paradigm also announced the issuance of two additional fungicide discovery patents. One of the new patents broadens the scope of Paradigm's proprietary TAG-KO® technology. It is a tool for the rapid and systematic mutation of pathogenic fungi, thereby enabling the efficient identification of novel antifungal and fungicide targets, as well as novel biosynthetic and degradation pathways. The second patent protects a fungicide target in the heme production pathway.
 
Paradigm Genetics is a biotechnology company using proprietary systems biology to discover biomarkers to reduce the cost, risk and time of product development, in addition to discovering inaccessible targets for small molecule discovery.