EFSA declares L-isoleucine as safe

 

 

Research conducted by the European Food Safety Authority (EFSA) found that amino acid L-isoleucine is both safe and effective as a feed additive.

 

L-isoleucine contains on a dry matter basis not less than 93.4% L-isoleucine, about 5% other amino acids and less than 1% unidentified impurities. It is produced by a GM E. coli K12 strain. The introduced genes do not trigger any safety concerns. The final product does not contain any cultivable production organism and the level of the recombinant DNA is below the limit of detection of the method used. 

 

Based on the available knowledge and studies in piglets, it is concluded that L-isoleucine is a source of available isoleucine and is safe for all animal species when added to diets to cover the animal requirement.

 

Data from additional toxicity studies supports L-isoleucine's safety and based on the fact that the consumer will not be exposed to additional isoleucine, it is concluded that no safety concerns for the consumer would result from the use of L-isoleucine as feed additive.

 

L-isoleucine is a physiological amino acid and a natural component of animals and plants whose use in animal nutrition would not lead to any localised increase in concentration in the environment. It is concluded that the use of the product as a feed additive does not present a foreseeable risk to the environment.