Evonik has now developed a test for chicken products that shows how the animals were kept and fed.

This new method, which was developed with the aid of epigenetics, enhances transparency and therefore raises consumer
confidence, the company said. Epigenetics is a branch of biology that determines how the environment an animal has been exposed to influences patterns on its genetic material. This means, for example, that it is possible to check that products declared as free-range are not actually mass-produced with the use of growth-promoting antibiotics.

Evonik sees potential users along the entire chicken production chain, especially agricultural enterprises and retailers. The epigenetic test will thus extend its range of system solutions for sustainable meat production.

Currently, experts are working to tailor the test method to the requirements of different customers. For this purpose, Evonik is building up an epigenetics and bioinformatics platform in Singapore. This will have around 10 employees in the future.

Development work is well advanced, so the specific tests can be made available to customers in the short- to mid-term.

Consumers should also benefit through greater transparency about the food on their plates.

Walter Pfefferle, a biologist who works as a manager at Creavis, Evonik's strategic research entity and business incubator, said: "Our technology opens up a completely new insight into poultry production. Chickens can now tell their own story."

As a new branch of science, epigenetics explains, for example, why cells in the liver or muscle develop differently despite identical genomes, and why appearance changes with age. Using the knowledge provided by epigenetics and artificial intelligence, scientists derived the first epigenetic clock for humans about 10 years ago. This provides information on their biological age.

Researchers at Evonik have now developed a similar epigenetic clock for chicken in collaboration with the team working with Prof. Frank Lyko, who heads the Epigenetics department at the German Cancer Research Center (DKFZ) in Heidelberg.

To this end, the team analysed the methylation sites in the chicken genome. These occur when methyl groups are transmitted to selected sites in the genome by enzymes. "Genes are activated and deactivated at these methylation sites," said Pfefferle. "Environmental signals influence the enzymes that trigger methylation. In this way, environmental influences leave their mark."

The scientists have identified more than 20 million methylation sites in the chicken genome. Depending on the methylation pattern, they show what the chicken has experienced. Artificial intelligence (AI) and algorithms help to analyse and interpret the data.

In cooperation with Illumina, a leading provider of systems for large-scale analysis of genetic variation and function, Evonik has now developed an epigenetic chip that allows rapid analysis of, for example, samples of meat, despite the enormous amount of data.

A pretreated sample is applied to a test area on the chip, which measures changes in the genome of the sample. The data can be read with a special appliance and are then evaluated using AI-based algorithms. At its laboratories in Singapore, Evonik is now validating the method, feeding data to the algorithms and exploring new areas of application.

In the coming months, the experts at Creavis aim to find out which factors are important for potential customers in the retail, meat processing,and agricultural sectors.

Simple evidence of the health and welfare of livestock, farming methods, performance-enhancing antibiotics, medication, origin and the method of slaughter is now available.

Pfefferle said: "Sustainable poultry production that explicitly takes animal welfare into account is becoming realistic."

With the aid of modern science, Evonik now has a technology that can make an appreciable contribution to the European Union's farm-tofork strategy.
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