June 23, 2020


Washington State University identifies five proteins that can be used for cattle vaccine


Researchers from Washington State University (WSU) investigating the Anaplasma marginale (A. marginale) bacteria behind the anaplasmosis disease have found five proteins that could be used to combat the disease, the Washington State University reported.


Kelly Brayton, a professor atWSU's Department of Veterinary Microbiology and Pathologysaid A. marginale is bacteria spread by ticks, which infects cattle's red blood cells causing anaplasmosis.


Brayton said anaplasmosis causes US$300 million in annual losses in the US.


Susan Noh, a research molecular biologist from the US Department of Agriculture Agricultural Research Service said while anaplasmosis antibiotics are available, it does not remove the infection. The infection remains in the cow and can spread to other livestock.


Brayton said the current blood-borne vaccine against A. marginale in use at South Africa is not approved in the United States as it could spread other diseases. Brayton and her colleagues in South Africa identified similar genes in A. marginale in the US and South Africa through comparative genomics.


Give potential proteins have been found that could be used to develop a vaccine to fight A. marginale. These are Am779, Am854, omp7, omp8 and omp9, located on the bacteria's outer membrane and is similar genetically in both the US and South Africa.

The proteins will now have to be produced for tests on cattle. Brayton said if the protein provides A. marginale immunity, researchers will then be able to challenge the cattle's immune response against other strains.


-      Washington State University