The combination of spray dried plasma and reduced crude protein in diets decreases circulating cytokines of weanling pigs

Tuesday, June 7, 2022


The combination of spray dried plasma and reduced crude protein in diets decreases circulating cytokines of weanling pigs


Hannah M. Bailey, Joy M. Campbell, and Hans H. Stein and APC

 

 

During the initial 2 week post-wean, dietary approaches may be implemented to alleviate effects of weaning stress on pigs. Inclusion of Spray Dried Plasma (SDP) in the diet may improve diet palatability, increase amino acid digestibility, and mitigate intestinal inflammation, resulting in improved growth performance of pigs. Additionally, decreasing crude protein (CP) in the diet may be effective in reducing post-weaning diarrhoea due to reduced fermentation of CP by microorganisms, but may also reduce growth performance of pigs.


The hypothesis that Spray Dried Plasma (SDP) complements low crude protein (CP) in diets by improving growth performance, decreasing diarrhoea, and reducing inflammation of pigs was tested in a 2-wk experiment with 160 pigs (5.89±0.39kg).

 
 

Four isocaloric diets were formulated: 2 diets with 23% CP without or with 6% SDP and 2 diets with 18.5% CP (standardized ileal digestible indispensable amino acids were reduced ~15%) without or with SDP. In both diets, SDP replaced soy protein concentrate. There were 8 pens/diet and 5 pigs/pen. Growth performance was recorded; diarrhoea was assessed every other day; blood samples were collected on d7 and d14; and intestinal tissue and mucosa were collected on d14.


Data were analyzed as a 2×2 factorial using PROC-MIXED of SAS. Pigs fed 23% CP had greater (P<0.05) average daily gain (ADG), average daily feed intake (ADFI), gain to feed ratio (G:F), and final body weight than pigs fed 18.5% CP. Pigs fed 6% SDP had greater (P<0.05) ADG, ADFI, G:F, and final body weight than pigs fed 0% SDP. Pigs fed 18.5% CP had less (P<0.05) diarrhoea than pigs fed 23% CP, whereas SDP did not influence diarrhoea.

 

No interaction between inclusion of SDP and level of CP for growth performance parameters or diarrhoea incidence; therefore, main effects are shown.

 


 

Ileal villus height and colonic mucosa width increased if SDP was included in the 23% CP diet, but not in the 18.5% CP diet (interaction, P<0.05). Ileal mucosa interleukin-12 was reduced if 6% SDP was combined with 23% CP, but increased if 6% SDP was combined with 18.5% CP (interaction, P<0.05). Circulating interleukin-2 decreased and interferon-gamma, interleukin-6, and interleukin-18 tended to decrease if 6% SDP was combined with 18.5% CP, but not with 23% CP (interaction, P<0.05 and P<0.10, respectively).

 


In conclusion, the combination of inclusion of SDP and reduced CP in the diets did not influence growth performance or diarrhoea incidence of weaned pigs, but resulted in decreased circulating pro-inflammatory cytokines, indicating reduced inflammatory response in weanling pigs.

 

 

For more of the article, please click here.


Article made possible through the contribution of Hannah M. Bailey, Joy M. Campbell, and Hans H. Stein and APC

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